Alzheimer’s Disease and Paraoxonase 1 () Gene Polymorphisms
نویسندگان
چکیده
منابع مشابه
Alzheimer’s Disease and Paraoxonase 1 (PON1) Gene Polymorphisms
BACKGROUND Some studies have indicated that human paraoxonase 1 (PON1) activity shows a polymorphic distribution. The aim of this study was to determine the distribution of PON1 polymorphism in patients with Alzheimer's disease in Gorgan and compare it with a healthy control group. METHOD The study included 100 healthy individuals and 50 patients. Enzyme activity and genetic polymorphism of P...
متن کاملParaoxonase 1 gene polymorphisms and enzyme activities in diabetes mellitus.
Paraoxonase 1 (PON1), an antioxidant enzyme closely associated with HDL (high-density lipoproteins), preserves LDL (low-density lipoproteins) against oxidation. Less protection may be therefore supposed by decreased PON1 activity. This study was undertaken to investigate the association of PON1 gene polymorphisms with diabetic angiopathy and to evaluate the relationship of these polymorphisms w...
متن کاملParaoxonase 1 (PON1) Activity, Polymorphisms and Coronary Artery Disease
Cardiovascular disorders (CVD) which include coronary artery disease (CAD), heart failure (HF) and stroke are the leading cause of morbidity and mortality both in developed and developing countries and by 2020 CAD is expected to become the number one cause of death worldwide 1-3. As per WHO, CVD kills nearly 17.5 million persons worldwide each year and is likely to continue to remain number one...
متن کاملEffects of paraoxonase 1 gene polymorphisms on heart diseases
BACKGROUND Associations between paraoxonase 1 (PON1) gene polymorphisms and heart diseases (HD) risk remain inconsistent. In order to obtain address this issue we performed a meta-analysis to assess the association between the L55M and Q192R polymorphisms of PON1 gene and heart diseases risk. METHODS Relevant studies were enrolled by searching databases systematically. Odds ratios (ORs) with ...
متن کاملParaoxonase-1 gene in patients with chronic obstructive pulmonary disease investigation Q192R and L55M polymorphisms.
BACKGROUND The effect of increased oxidative stress on the development of chronic obstructive pulmonary disease (COPD) is well known. One of the antioxidative systems against oxidative stress in human body is paraoxonase (PON) enzyme that protects low density lipoproteins (LDL) against oxidation. This study aimed to explore the polymorphisms on PON1, Q192R, L55M genes of patients with COPD. M...
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ژورنال
عنوان ژورنال: The Open Biochemistry Journal
سال: 2017
ISSN: 1874-091X
DOI: 10.2174/1874091x01711010047